Invention Grant
US08729265B2 Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
有权
2-氨基-5-三氟甲基嘧啶衍生物的区域选择性制备
- Patent Title: Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
- Patent Title (中): 2-氨基-5-三氟甲基嘧啶衍生物的区域选择性制备
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Application No.: US13389068Application Date: 2010-08-13
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Publication No.: US08729265B2Publication Date: 2014-05-20
- Inventor: Guenter Linz , Gerd Kraemer
- Applicant: Guenter Linz , Gerd Kraemer
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Mary-Ellen M. Devlin
- Priority: EP09167935 20090814
- International Application: PCT/EP2010/061839 WO 20100813
- International Announcement: WO2011/018517 WO 20110217
- Main IPC: C07D239/34
- IPC: C07D239/34 ; C07D239/30
Abstract:
The present invention relates to a method of making pyrimidines of formula (III) said method comprising reacting a compound of formula (I) with an oxygen, sulfur or nitrogen nucleophile of formula T-H; and reacting the compound obtained with an amine of formula (II) [HN(R1)R2] to form a compound of formula (III) wherein X1, X2, T, R1 and R2 have the meanings as defined herein.
Public/Granted literature
- US20120172596A1 REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES Public/Granted day:2012-07-05
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