Invention Grant
- Patent Title: Preparation of N-alkylated opiates by reductive amination
- Patent Title (中): 通过还原胺化制备N-烷基化的鸦片剂
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Application No.: US12668900Application Date: 2008-06-16
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Publication No.: US08729266B2Publication Date: 2014-05-20
- Inventor: Christopher W. Grote , Brian Orr , Tao Jiang , Gary L. Cantrell
- Applicant: Christopher W. Grote , Brian Orr , Tao Jiang , Gary L. Cantrell
- Applicant Address: US MO Hazelwood
- Assignee: Mallinckrodt LLC
- Current Assignee: Mallinckrodt LLC
- Current Assignee Address: US MO Hazelwood
- International Application: PCT/US2008/067058 WO 20080616
- International Announcement: WO2009/012005 WO 20090122
- Main IPC: C07D489/02
- IPC: C07D489/02
Abstract:
The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
Public/Granted literature
- US20100197921A1 Preparation of N-Alkylated Opiates by Reductive Amination Public/Granted day:2010-08-05
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