Invention Grant
US08729303B2 2,2′,6,6′-tetrasubstituted aminophosphine ligand and its synthesis method
有权
2,2',6,6'-四取代氨基膦配体及其合成方法
- Patent Title: 2,2′,6,6′-tetrasubstituted aminophosphine ligand and its synthesis method
- Patent Title (中): 2,2',6,6'-四取代氨基膦配体及其合成方法
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Application No.: US12377000Application Date: 2007-08-10
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Publication No.: US08729303B2Publication Date: 2014-05-20
- Inventor: Wanbin Zhang , Fang Xie , Fang Fang
- Applicant: Wanbin Zhang , Fang Xie , Fang Fang
- Applicant Address: CN Shanghai
- Assignee: Shanghai Jiaotong University
- Current Assignee: Shanghai Jiaotong University
- Current Assignee Address: CN Shanghai
- Agency: Westerman, Hattori, Daniels & Adrian, LLP
- Priority: CN200610029881 20060810
- International Application: PCT/CN2007/002407 WO 20070810
- International Announcement: WO2008/019598 WO 20080221
- Main IPC: C07F9/02
- IPC: C07F9/02

Abstract:
The present invention relates to a 2,2′,6,6′-tetrasubstituted aminophosphine ligand and its synthesis method. The structure of the ligand is shown as below. Its synthesis method comprises: Step (1) coupling 2,6-dinitrochlorobenzene as the starting material to obtain 2,2′,6,6′-tetranitrobiphenyl; Step (2): hydrogenating the 2,2′,6,6′-tetranitrobiphenyl with Pd/C to obtain 2,2′,6,6′-tetraminobiphenyl; Step (3): reacting the 2,2′,6,6′-tetraminobiphenyl with a phosphine halide to obtain the 2,2′,6,6′-tetrasubstituted aminophosphine ligand. The ligand of the present invention is an achiral compound, and its preparation method is simple. The ligand can be converted to a chiral bimetallic catalyst with single configuration eventually through introduction of external chirality. Moreover, the ligand can be used in various asymmetric reaction catalyzed by metals with high reactivity and stereoselectivity.
Public/Granted literature
- US20100217040A1 2, 2', 6, 6'- TETRASUBSTITUTED AMINOPHOSPHINE LIGAND AND ITS SYNTHESIS METHOD Public/Granted day:2010-08-26
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