Invention Grant
- Patent Title: Process for the preparation of tapentadol and intermediates thereof
- Patent Title (中): 制备他喷他多的方法及其中间体
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Application No.: US13512989Application Date: 2010-11-30
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Publication No.: US08729308B2Publication Date: 2014-05-20
- Inventor: Giuseppe Motta , Domenico Vergani , Giorgio Bertolini
- Applicant: Giuseppe Motta , Domenico Vergani , Giorgio Bertolini
- Applicant Address: IT Milan
- Assignee: Euticals S.p.A.
- Current Assignee: Euticals S.p.A.
- Current Assignee Address: IT Milan
- Agency: Hueschen and Sage
- Priority: ITMI2009A2110 20091201
- International Application: PCT/IB2010/055499 WO 20101130
- International Announcement: WO2011/067714 WO 20110609
- Main IPC: C07C211/00
- IPC: C07C211/00 ; C07C221/00 ; C07C225/00 ; C07C223/00
Abstract:
The present invention refers to a new process for the synthesis of tapentadol comprising the quantitative resolution of the racemic mixture (V) to obtain the stereoisomer of (S)-3-(dimethylamino)-2-methyl-1-(3-nitrophenyl)-propan-1-one (VII) according to the Scheme 2 below using the (2R,3R)—O,O′-dibenzoyltartaric chiral acid wherein said resolution is quantitative. The present invention also refers to some intermediate compounds of the new synthesis process of tapentadol.
Public/Granted literature
- US20120232306A1 PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF Public/Granted day:2012-09-13
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