Provided is a method for managing resource in a high capacity wireless communication system capable of communicating with two or more users in a multi-input multi-output (MIMO) scheme when a base station transmits data. The includes: transmitting a MU-MIMO request-to-send (RTS) message to stations intending to transmit data in the MIMO scheme, and sequentially receiving a clear-to-send (CTS) message from stations intending to receive the data; transmitting a transmission ACK message to the stations, wherein the transmission ACK message includes information which prevents data collision during a time of data transmission to the stations and ACK signal; and configuring data to be transmitted to the stations into aggregated packets (A-MPDUs), transmitting the A-MPDUs to the stations in the MIMO scheme, and receiving a block ACK message from the stations.