One or more multi-electrode lead coupled to a cardiac sensor/stimulator. Each lead includes a lead body extending from one lead proximal end portion to one lead distal end portion. Each lead further includes at least three tissue sensing/stimulation electrodes disposed along the lead body and at least three terminal connections disposed along the lead proximal end. The tissue sensing/stimulation electrodes are each adapted to sense or stimulate a subject's heart. The cardiac sensor/stimulator includes a signal processing circuit adapted to sense the heart in a first instance and stimulate the heart in a second instance by way of one or more tissue electrode configurations. The configurations are selectable from any combination of the tissue sensing/stimulation electrodes of each implanted lead and an indifferent return electrode. In one example, the signal processing circuit automatically selects the tissue electrode configurations. In another example, a user (manually) selects the tissue electrode configurations.