Systems and methods for providing vehicle-centric collision avoidance are disclosed. An example method includes determining a first flight trajectory for a first aircraft, determining a second flight trajectory for a second aircraft, determining a predicted first distance between the first aircraft and the second aircraft at a first closest point of approach based on the first and second flight trajectories, comparing the predicted first distance to a first separation perimeter layer, the first separation perimeter layer defining a first three-dimensional perimeter based on the first aircraft, determining a first adjustment having a first magnitude from the first flight trajectory when the predicted first distance is within a first perimeter, determining a second adjustment having a second magnitude from the first flight trajectory when the predicted first distance is within a second perimeter different from the first perimeter, and altering the first flight trajectory based on the first or second adjustment.