The medical protective cover includes a semi-ovoid shell configured to cover a wound or intravenous site. The shell is attached to a patient's limb or extremity by a pair of adhesive tabs extending from longitudinal ends of the shell and a plurality of adjustable straps extending laterally from the shell. A plurality of ventilation holes longitudinally extend along lateral edges of the shell to allow passage of air for keeping the covered area dry. Each longitudinal end of the shell includes a pair of tubing ports to facilitate mounting and passage of IV infusion tubing to an IV catheter or cannula. The top of the shell also includes a selectively opened slot that permits passage of a needle for the administration or withdrawal of fluids through an access port of the catheter.