A method of operating an isolation valve can include transmitting a signal to a detector section of the isolation valve, and a control system of the isolation valve operating an actuator of the isolation valve in response to detection of the signal by the detector section. An isolation valve can include a detector section which detects a presence of an object in the isolation valve, and a control system which operates an actuator of the isolation valve in response to an object presence indication received from the detector section. A well system can include an isolation valve which selectively permits and prevents fluid communication between sections of a wellbore, the isolation valve including a detector section which detects a signal, and the isolation valve further including a control system which operates an actuator of the isolation valve in response to detection of the signal by the detector section.