Proposed is a dispenser for discharging at least one flowable component from a cartridge. The dispenser comprises a cartridge holder (110) and an advancing element (120) that is slidable therein. A cartridge (200) can be axially inserted into the cartridge holder against a direction of advancing (V). In order to axially fix the cartridge, a rotating element (140) has been provided on the cartridge holder. In a first orientation the cartridge can be slid into the cartridge holder against the direction of advancing, while in the second orientation the rotating element axially fixes the inserted cartridge. Furthermore, in a third orientation the rotating element can be rotatable on the rotary axis in order to open at least one outlet opening of the cartridge.