The invention relates to a negative-pressure ink cartridge refilling device, system and method. The device comprises an ink container used to store ink, an ink injection channel, an aspirator and a suction channel communicated with the ink container, wherein one end of the ink injection channel is an ink inlet end while the other end is an ink outlet end connected with the ink cartridge to be refilled; a sucking opening connected with the aspirator is formed on the suction channel; and the inlet end is disposed above the ink level surface of the ink container. Therefore, the ink in the ink container cannot be overflowed via the ink injection channel regardless of the environmental factors, and thus the technical problem that the phenomenon of ink splash tends to occur when the traditional negative-pressure ink cartridge refilling device is used by a user for the first time can be solved.