Invention Grant
- Patent Title: Responsive MRI contrast agents
- Patent Title (中): 响应性MRI造影剂
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Application No.: US11912694Application Date: 2006-04-21
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Publication No.: US08734761B2Publication Date: 2014-05-27
- Inventor: Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell
- Applicant: Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell
- Applicant Address: NL Eindhoven
- Assignee: Koninklijke Philips N.V.
- Current Assignee: Koninklijke Philips N.V.
- Current Assignee Address: NL Eindhoven
- Priority: EP05103356 20050426
- International Application: PCT/IB2006/051235 WO 20060421
- International Announcement: WO2006/114738 WO 20061102
- Main IPC: A61B5/055
- IPC: A61B5/055
Abstract:
The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localized inflammation respectively.
Public/Granted literature
- US20080193384A1 Responsive Mri Contrast Agents Public/Granted day:2008-08-14
Information query
