Invention Grant
US08734775B2 Chemokine derived peptides that bind with chemokine receptor CXCR3 and uses for chronic wound and angiogenesis inhibition treatments
有权
与趋化因子受体CXCR3结合并用于慢性伤口和血管发生抑制治疗的趋化因子衍生肽
- Patent Title: Chemokine derived peptides that bind with chemokine receptor CXCR3 and uses for chronic wound and angiogenesis inhibition treatments
- Patent Title (中): 与趋化因子受体CXCR3结合并用于慢性伤口和血管发生抑制治疗的趋化因子衍生肽
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Application No.: US13219375Application Date: 2011-08-26
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Publication No.: US08734775B2Publication Date: 2014-05-27
- Inventor: Cecelia C. Yates-Binder , Jesse Jaynes , Timothy Turner , Alan Wells , Richard J. Bodnar
- Applicant: Cecelia C. Yates-Binder , Jesse Jaynes , Timothy Turner , Alan Wells , Richard J. Bodnar
- Applicant Address: US PA Pittsburgh US AL Tuskegee
- Assignee: University of Pittsburgh,Tuskegee University
- Current Assignee: University of Pittsburgh,Tuskegee University
- Current Assignee Address: US PA Pittsburgh US AL Tuskegee
- Agency: Hogan Lovells US LLP
- Main IPC: A61K38/19
- IPC: A61K38/19 ; A61K45/00 ; C07K14/435
Abstract:
Disclosed are peptides having activity against receptor CXCR3 are disclosed that exhibit activity in preventing the formation of new vessels and activity in mediating the dissociation of newly-formed vessels and resolving of wounds in the later stages of wound healing. Preferred peptides are derived from the α-helix portion IP-10 (CXCL10) or from IP-9 (CXCL11), are nontoxic, and smaller than naturally occurring peptides, making them useful in therapies against diseases or disease states marked by unwanted angiogenesis, including tumorogenic diseases such as cancers, and in healing of chronic wounds.
Public/Granted literature
- US20130053319A1 CHEMOKINE DERIVED PEPTIDES AND USES FOR CHRONIC WOUND AND ANGIOGENESIS INHIBITION TREATMENTS Public/Granted day:2013-02-28
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