Invention Grant
US08734829B2 Medical devices having polymeric nanoporous coatings for controlled therapeutic agent delivery and a nonpolymeric macroporous protective layer
有权
具有用于受控治疗剂递送的聚合纳米多孔涂层和非聚合性大孔保护层的医疗装置
- Patent Title: Medical devices having polymeric nanoporous coatings for controlled therapeutic agent delivery and a nonpolymeric macroporous protective layer
- Patent Title (中): 具有用于受控治疗剂递送的聚合纳米多孔涂层和非聚合性大孔保护层的医疗装置
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Application No.: US12703946Application Date: 2010-02-11
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Publication No.: US08734829B2Publication Date: 2014-05-27
- Inventor: Jan Weber
- Applicant: Jan Weber
- Applicant Address: US MN Maple Grove
- Assignee: Boston Scientific Scimed, Inc.
- Current Assignee: Boston Scientific Scimed, Inc.
- Current Assignee Address: US MN Maple Grove
- Agency: Fish & Richardson P.C.
- Main IPC: A61F2/00
- IPC: A61F2/00 ; A61L33/00 ; B05D3/00 ; C23C14/00 ; C23C14/32
Abstract:
An implantable or insertable medical device is provided which contains the following: (a) a substrate, (b) a therapeutic agent-containable region disposed over the substrate, (c) a nanoporous polymeric layer disposed over the therapeutic agent-containable region and (d) a macroporous non-polymeric layer disposed over the nanoporous polymeric layer. The nanoporous polymeric layer largely regulates transport of species between the therapeutic agent-containable region and the exterior of the device. The macroporous non-polymeric layer has a larger pore size than the nanoporous polymeric layer and largely serves to isolate the polymeric material from surrounding tissue during in-situ delivery of the therapeutic agents.
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