Invention Grant
- Patent Title: Oral medicinal product with modified release of at least one active principle in multimicrocapsular form
- Patent Title (中): 具有多微囊形式的至少一种活性成分释放的口服药物
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Application No.: US10996780Application Date: 2004-11-24
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Publication No.: US08734850B2Publication Date: 2014-05-27
- Inventor: Catherine Castan , Florence Guimberteau , Remi Meyrueix , Gerard Soula
- Applicant: Catherine Castan , Florence Guimberteau , Remi Meyrueix , Gerard Soula
- Applicant Address: FR Venissieux
- Assignee: Flamel Technologies
- Current Assignee: Flamel Technologies
- Current Assignee Address: FR Venissieux
- Agency: Patton Boggs LLP
- Main IPC: A61K9/16
- IPC: A61K9/16 ; A61K9/22

Abstract:
The field of the invention is that of oral pharmaceutical medicinal products or compositions, more particularly of the type of those comprising one or more active principles.The aim of the invention is to provide an improved oral medicinal product that can be administered in one or more daily doses, with modified release of active principle (in particular an active principle), for improving the prophylactic and therapeutic efficacy of such a medicinal product.This aim is achieved by means of the multimicrocapsular oral pharmaceutical form according to the invention in which the release of the AP is controlled by means of a double mechanism of triggering the release: “time triggering” and “pH triggering”. This medicinal product comprises microcapsules with modified release of active principle, each containing a core comprising the active principle and one or more swelling agents, and at least one coating making possible the modified release of the active principle.
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