Invention Grant
- Patent Title: Localized delivery of nucleic acid by polyelectrolyte assemblies
- Patent Title (中): 通过聚电解质组件局部递送核酸
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Application No.: US11414818Application Date: 2006-05-01
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Publication No.: US08734851B2Publication Date: 2014-05-27
- Inventor: David M. Lynn , Jingtao Zhang , Christopher M. Jewell , Nathaniel J. Fredin
- Applicant: David M. Lynn , Jingtao Zhang , Christopher M. Jewell , Nathaniel J. Fredin
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Lathrop & Gage LLP
- Main IPC: A61K9/16
- IPC: A61K9/16 ; A61K9/14 ; A61K47/44 ; C12Q1/68 ; C12N15/00 ; C12N15/88 ; C12N15/87
Abstract:
The present invention provides implantable medical devices coated with polyelectrolyte assemblies that are fabricated by layer-by-layer deposition of nucleic acid and polycation. Such devices facilitate the local delivery of a nucleic acid contained in the polyelectrolyte assembly into a cell or tissue at an implantation site. Also provided are methods of fabricating and using implantable medical devices according to the invention.
Public/Granted literature
- US20060251701A1 Localized delivery of nucleic acid by polyelectrolyte assemblies Public/Granted day:2006-11-09
Information query
