Invention Grant
- Patent Title: HDL particles for delivery of nucleic acids
- Patent Title (中): 用于递送核酸的HDL颗粒
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Application No.: US13129349Application Date: 2009-11-17
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Publication No.: US08734853B2Publication Date: 2014-05-27
- Inventor: Anil K. Sood , Andras G. Lacko , Gabriel Lopez-Berestein , Lingegowda S. Mangala , Walter J. McConathy , Laszlo Prokai , Maya P. Nair
- Applicant: Anil K. Sood , Andras G. Lacko , Gabriel Lopez-Berestein , Lingegowda S. Mangala , Walter J. McConathy , Laszlo Prokai , Maya P. Nair
- Applicant Address: US TX Fort Worth US TX Austin
- Assignee: University of North Texas Health Science Center at Fort Worth,The Board of Regents, The University of Texas System
- Current Assignee: University of North Texas Health Science Center at Fort Worth,The Board of Regents, The University of Texas System
- Current Assignee Address: US TX Fort Worth US TX Austin
- Agency: Parker Highlander PLLC
- International Application: PCT/US2009/064834 WO 20091117
- International Announcement: WO2010/057203 WO 20100520
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K31/7088 ; A61K31/7105
Abstract:
Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits.
Public/Granted literature
- US20110312899A1 HDL Particles for Delivery of Nucleic Acids Public/Granted day:2011-12-22
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