Invention Grant
US08735081B2 T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
有权
T1R异低聚味觉受体，表达所述受体的细胞系和味觉化合物
- Patent Title: T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
- Patent Title (中): T1R异低聚味觉受体，表达所述受体的细胞系和味觉化合物
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Application No.: US13417660Application Date: 2012-03-12
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Publication No.: US08735081B2Publication Date: 2014-05-27
- Inventor: Xiaodong Li , Lena Staszewski , Hong Xu
- Applicant: Xiaodong Li , Lena Staszewski , Hong Xu
- Applicant Address: US CA San Diego
- Assignee: Senomyx, Inc.
- Current Assignee: Senomyx, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Cooley LLP
- Main IPC: C07K19/00
- IPC: C07K19/00 ; C07K14/705 ; G01N33/567 ; C12N15/62
Abstract:
The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.
Public/Granted literature
- US20130030059A1 T1R HETERO-OLIGOMERIC TASTE RECEPTORS, CELL LINES THAT EXPRESS SAID RECEPTORS, AND TASTE COMPOUNDS Public/Granted day:2013-01-31
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