Invention Grant
- Patent Title: DNA polymerases with increased 3′-match discrimination
-
Application No.: US13162674Application Date: 2011-06-17
-
Publication No.: US08735121B2Publication Date: 2014-05-27
- Inventor: Fred Reichert , Keith Bauer , Thomas W. Myers
- Applicant: Fred Reichert , Keith Bauer , Thomas W. Myers
- Applicant Address: US CA Pleasanton
- Assignee: Roche Molecular Systems, Inc.
- Current Assignee: Roche Molecular Systems, Inc.
- Current Assignee Address: US CA Pleasanton
- Agency: Kilpatrick Townsend & Kilpatrick LLP
- Main IPC: C12N9/00
- IPC: C12N9/00 ; C12N15/54

Abstract:
Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
Public/Granted literature
- US20120015405A1 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION Public/Granted day:2012-01-19
Information query