Invention Grant
US08735124B2 Isolated PON1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
有权
分离的PON1多肽，编码它们的多核苷酸及其在治疗或预防有机磷酸盐暴露相关损伤中的用途
- Patent Title: Isolated PON1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
- Patent Title (中): 分离的PON1多肽，编码它们的多核苷酸及其在治疗或预防有机磷酸盐暴露相关损伤中的用途
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Application No.: US13420920Application Date: 2012-03-15
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Publication No.: US08735124B2Publication Date: 2014-05-27
- Inventor: Dan S. Tawfik , Rinkoo Devi Gupta , Moshe Goldsmith , Yaacov Ashani
- Applicant: Dan S. Tawfik , Rinkoo Devi Gupta , Moshe Goldsmith , Yaacov Ashani
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- Main IPC: C12N9/16
- IPC: C12N9/16 ; C12N9/14 ; C12P21/06 ; C12P19/34 ; C12N15/00 ; C07H21/04 ; C07K1/00 ; A01N25/34 ; A61K9/00 ; A61K38/46
Abstract:
An isolated polypeptide comprising the amino acid sequence of serum paraoxonase (PON1) having catalytic efficiency of kcat/KM≈106-5·107 M−1min−1 for a G-type organophosphate.
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