Invention Grant
- Patent Title: Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers and photoamplified fluorescence turn-off system
- Patent Title (中): 在光敏光敏剂和光扩增荧光关断系统中通过外部致敏的光致变色引发的光诱导信号放大
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Application No.: US12672105Application Date: 2008-08-20
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Publication No.: US08735167B2Publication Date: 2014-05-27
- Inventor: Andrei G. Kutateladze , Alexei Kurchan , Rudresha Kottani , Janaki Majjigapu
- Applicant: Andrei G. Kutateladze , Alexei Kurchan , Rudresha Kottani , Janaki Majjigapu
- Applicant Address: US CO Denver
- Assignee: Colorado Seminary, which owns and operates The University of Denver
- Current Assignee: Colorado Seminary, which owns and operates The University of Denver
- Current Assignee Address: US CO Denver
- Agency: Lathrop & Gage LLP
- International Application: PCT/US2008/073637 WO 20080820
- International Announcement: WO2009/026313 WO 20090226
- Main IPC: G01N21/76
- IPC: G01N21/76
Abstract:
Provided is a photoamplified fluorescence turn-off assay where a masked photosensitizer is mixed with a fluorescent molecule. This mixture is brightly fluorescent because the masked photosensitizer is not capable of quenching the fluorophore. When the photosensitizer is released and amplified, the photosensitizer quenches the emission of fluorophores very efficiently.
Public/Granted literature
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