Invention Grant
US08735344B2 Sustained release of APO A-I mimetic peptides and methods of treatment
有权
APO A-I模拟肽的持续释放和治疗方法
- Patent Title: Sustained release of APO A-I mimetic peptides and methods of treatment
- Patent Title (中): APO A-I模拟肽的持续释放和治疗方法
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Application No.: US13177476Application Date: 2011-07-06
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Publication No.: US08735344B2Publication Date: 2014-05-27
- Inventor: Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
- Applicant: Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
- Applicant Address: US CA Santa Clara
- Assignee: Abbott Cardiovascular Systems Inc.
- Current Assignee: Abbott Cardiovascular Systems Inc.
- Current Assignee Address: US CA Santa Clara
- Agency: Blakely Sokoloff Taylor & Zafman LLP
- Agent Randy Shen
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K38/00

Abstract:
A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
Public/Granted literature
- US20110262530A1 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT Public/Granted day:2011-10-27
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