Invention Grant
US08735355B2 Methods of use of fragments of secreted frizzled related protein, sFRP
有权
分泌性卷曲相关蛋白（sFRP）片段的使用方法
- Patent Title: Methods of use of fragments of secreted frizzled related protein, sFRP
- Patent Title (中): 分泌性卷曲相关蛋白（sFRP）片段的使用方法
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Application No.: US13426520Application Date: 2012-03-21
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Publication No.: US08735355B2Publication Date: 2014-05-27
- Inventor: Jeffrey S. Rubin , Susan Cumberledge , Frieda Reichsman , Aykut Uren
- Applicant: Jeffrey S. Rubin , Susan Cumberledge , Frieda Reichsman , Aykut Uren
- Applicant Address: US DC Washington US MA Amherst
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services,University of Massachusetts
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services,University of Massachusetts
- Current Assignee Address: US DC Washington US MA Amherst
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K39/00 ; A61P35/00 ; C07K14/00
Abstract:
The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
Public/Granted literature
- US20120202749A1 SECRETED FRIZZLED RELATED PROTEIN, SFRP, FRAGMENTS AND METHODS OF USE THEREOF Public/Granted day:2012-08-09
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