Invention Grant
- Patent Title: Compositions and methods for altering RNAi
- Patent Title (中): 用于改变RNAi的组合物和方法
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Application No.: US13668441Application Date: 2012-11-05
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Publication No.: US08735371B2Publication Date: 2014-05-27
- Inventor: Richard William Carthew , Young Sik Lee , Dinari Harris
- Applicant: Northwestern University
- Applicant Address: US IL Evanston
- Assignee: Northwestern University
- Current Assignee: Northwestern University
- Current Assignee Address: US IL Evanston
- Agency: Casimir Jones, S.C.
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04
Abstract:
The present invention relates to compositions and methods for altering (e.g., enhancing) RNAi. In particular, the present invention provides systems and methods for identifying regulators of RNAi. For example, the present invention provides RNAi regulators (e.g., HPS1 and HPS4) and methods of altering (e.g., inhibiting) these regulators in order to alter (e.g., enhance) RNAi. The present invention also provides methods of identifying inhibitors (e.g., small molecule, nucleic acid (e.g., siRNA), and antibody) of RNAi regulators and methods of using the same (e.g., to enhance RNAi). Compositions and methods of the present invention find use in research (e.g., functional genomics), therapeutic (e.g., drug discovery and delivery) and clinical applications.
Public/Granted literature
- US20130131145A1 COMPOSITIONS AND METHODS FOR ALTERING RNAi Public/Granted day:2013-05-23
Information query
