Invention Grant
US08735385B2 Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
有权
取代的苯基环烷基吡咯烷(哌啶)螺内酰胺和酰胺,其制备和治疗用途
- Patent Title: Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
- Patent Title (中): 取代的苯基环烷基吡咯烷(哌啶)螺内酰胺和酰胺,其制备和治疗用途
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Application No.: US13670111Application Date: 2012-11-06
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Publication No.: US08735385B2Publication Date: 2014-05-27
- Inventor: Zhongli Gao
- Applicant: Sanofi
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Main IPC: C07D207/06
- IPC: C07D207/06 ; C07D401/12 ; C07D403/10 ; C07D405/12 ; C07D409/12 ; C07D413/12 ; C07D417/10 ; C07D491/107 ; A61K31/407 ; A61K31/403 ; A61K31/438 ; A61K31/40

Abstract:
The present disclosure relates to a series of substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides of formula (Ia) and formula (Ib). wherein R1, R2, R3, R4, X, m, l, n, p and s are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this disclosure relates to methods of preparation of substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides of formula (Ia) and (Ib), and intermediates therefor.
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