Invention Grant
US08735392B2 Crystalline (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt
有权
结晶（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H-吡啶 [4,3,2-de]酞嗪-3（7H） - 酮甲苯磺酸盐
![Crystalline (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt](/docs/US/2014-05-27/US08735392B2/abs.jpg.600x600.jpg)
- Patent Title: Crystalline (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt
- Patent Title (中): 结晶（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H-吡啶 [4,3,2-de]酞嗪-3（7H） - 酮甲苯磺酸盐
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Application No.: US13277607Application Date: 2011-10-20
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Publication No.: US08735392B2Publication Date: 2014-05-27
- Inventor: Bing Wang , Daniel Chu , Yongbo Liu , Shichun Peng
- Applicant: Bing Wang , Daniel Chu , Yongbo Liu , Shichun Peng
- Applicant Address: US CA Novato
- Assignee: BioMarin Pharmaceutical Inc.
- Current Assignee: BioMarin Pharmaceutical Inc.
- Current Assignee Address: US CA Novato
- Agency: Jones Day
- Main IPC: A01N43/58
- IPC: A01N43/58 ; A61K31/495
![Crystalline (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt](/abs-image/US/2014/05/27/US08735392B2/abs.jpg.150x150.jpg)
Abstract:
Provided herein are (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt forms, including crystalline forms, and methods of their preparation. Pharmaceutical compositions comprising a (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt are also provided, as are methods of using (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt to treat a disease or condition, such as a cancer.
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