Invention Grant
- Patent Title: Benzamide compounds useful as histone deacetylase inhibitors
- Patent Title (中): 可用作组蛋白脱乙酰酶抑制剂的苯甲酰胺化合物
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Application No.: US13472095Application Date: 2012-05-15
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Publication No.: US08735429B2Publication Date: 2014-05-27
- Inventor: David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
- Applicant: David Michael Andrews , Elaine Sophie Elizabeth Stokes , Andrew Turner , Michael James Waring
- Applicant Address: SE Sodertalje
- Assignee: AstraZeneca AB
- Current Assignee: AstraZeneca AB
- Current Assignee Address: SE Sodertalje
- Priority: GB0521244.4 20051019
- Main IPC: A61K31/445
- IPC: A61K31/445

Abstract:
The invention concerns benzamide compounds of formula (I): compound of formula (I): wherein R1 is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).
Public/Granted literature
- US20120225907A1 BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS Public/Granted day:2012-09-06
Information query
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