Invention Grant
- Patent Title: Nitrated-fatty acids modulation of type II diabetes
- Patent Title (中): 硝酸脂肪酸调节II型糖尿病
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Application No.: US13666827Application Date: 2012-11-01
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Publication No.: US08735449B2Publication Date: 2014-05-27
- Inventor: Bruce A. Freeman
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Agency: Klarquist Sparkman LLP
- Main IPC: A61K31/20
- IPC: A61K31/20
Abstract:
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-γ.
Public/Granted literature
- US20130059912A1 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES Public/Granted day:2013-03-07
Information query
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