Invention Grant
US08735561B2 Virus-like particles of capsid proteins from human papillomavirus type 16/58/18/6/11 and the method for preparation and the uses thereof
有权
来自人乳头瘤病毒16/58/18/6/11型的衣壳蛋白病毒样颗粒及其制备方法及其用途
- Patent Title: Virus-like particles of capsid proteins from human papillomavirus type 16/58/18/6/11 and the method for preparation and the uses thereof
- Patent Title (中): 来自人乳头瘤病毒16/58/18/6/11型的衣壳蛋白病毒样颗粒及其制备方法及其用途
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Application No.: US12441393Application Date: 2007-09-18
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Publication No.: US08735561B2Publication Date: 2014-05-27
- Inventor: Xuemei Xu , Ting Zhang , Yufei Xu , Dongsheng Fan
- Applicant: Xuemei Xu , Ting Zhang , Yufei Xu , Dongsheng Fan
- Applicant Address: CN Beijing
- Assignee: Chinese Academy of Medical Sciences, Institute of Basic Medical Sciences
- Current Assignee: Chinese Academy of Medical Sciences, Institute of Basic Medical Sciences
- Current Assignee Address: CN Beijing
- Agency: Eagle IP Limited
- Agent Jacqueline C. Lui
- Priority: CN200610127387 20060918
- International Application: PCT/CN2007/070715 WO 20070918
- International Announcement: WO2008/034388 WO 20080327
- Main IPC: C12N15/37
- IPC: C12N15/37 ; C12N15/85 ; C12N1/21 ; C12N15/866
Abstract:
Five optimized genes of capsid L1 protein from human papillomavirus type 16, 58, 18, 6 and 11, which are modified by using insect's preferred codons and so on. Method for modifying those genes to express more highly in insect cells. Virus-like particle's vaccine compositions comprising HPV L1 proteins or their functional relatives produced by using those modified genes. Those optimized genes of L1 can be used to produce HPV 16 VLP, HPV 58VLP, HPV 18VLP, HPV 6 VLP, HPV 11VLP in insect cells. Yields of virus-like particles derived from those optimized HPV L1 genes are high. Mixed multivalent vaccines comprising above optimized HPV L1 genes can be used to prevent and treat multiple HPV infection and diseases related with it.
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