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US08735566B2 Bacterially derived intact minicells that encompass plasmid free functional nucleic acid for in vivo delivery to mammalian cells 有权
细菌衍生的完整小细胞,其包含用于体内递送至哺乳动物细胞的无质粒功能核酸

Bacterially derived intact minicells that encompass plasmid free functional nucleic acid for in vivo delivery to mammalian cells
Abstract:
Intact, bacterially-derived minicells can safely introduce therapeutically effective amounts of plasmid-free functional nucleic acid to target mammalian cells. To this end, functional nucleic acid can be packaged into intact minicells directly, without resort to expression constructs, the expression machinery of the host cell, harsh chemicals or electroporation.
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