Invention Grant
- Patent Title: Process for the synthesis of naratriptan
- Patent Title (中): 合成纳他曲坦的方法
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Application No.: US13390455Application Date: 2010-08-18
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Publication No.: US08735589B2Publication Date: 2014-05-27
- Inventor: Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan , Sandip Vasant Chikhalikar , Maruti Ghagare
- Applicant: Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan , Sandip Vasant Chikhalikar , Maruti Ghagare
- Applicant Address: IN Mumbai
- Assignee: Cipla Limited
- Current Assignee: Cipla Limited
- Current Assignee Address: IN Mumbai
- Agency: Conley Rose, P.C.
- Agent Rodney B. Carroll
- Priority: IN1931/MUM/2009 20090820
- International Application: PCT/GB2010/001562 WO 20100818
- International Announcement: WO2011/021000 WO 20110224
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07C255/50

Abstract:
The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z′ is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. The present invention also provides novel compounds (3) and (4) and processes for their preparation.
Public/Granted literature
- US20120220778A1 Process for the synthesis of naratriptan Public/Granted day:2012-08-30
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