Invention Grant
US08735596B2 Process for producing crystals of polymorphic 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecaboxylic acid by poor-solvent addition method
有权
通过不良溶剂添加法生产多晶型2-（3-氰基-4-异丁氧基苯基）-4-甲基-5-噻唑可可酸的晶体的方法
- Patent Title: Process for producing crystals of polymorphic 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecaboxylic acid by poor-solvent addition method
- Patent Title (中): 通过不良溶剂添加法生产多晶型2-（3-氰基-4-异丁氧基苯基）-4-甲基-5-噻唑可可酸的晶体的方法
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Application No.: US13382264Application Date: 2010-07-14
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Publication No.: US08735596B2Publication Date: 2014-05-27
- Inventor: Akihito Uemura , Tomoaki Nogata , Takumi Takeyasu
- Applicant: Akihito Uemura , Tomoaki Nogata , Takumi Takeyasu
- Applicant Address: JP Tokyo
- Assignee: Teijin Pharma Limited
- Current Assignee: Teijin Pharma Limited
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JP2009-166755 20090715
- International Application: PCT/JP2010/062291 WO 20100714
- International Announcement: WO2011/007895 WO 20110120
- Main IPC: C07D277/34
- IPC: C07D277/34
Abstract:
Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected from the group consisting of 1-propanol, 2-propanol, ethanol, and acetone; a step of cooling the solution; and a step of adding to the solution a hydrocarbon solvent as a poor solvent.
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