Invention Grant
- Patent Title: Dual-acting antihypertensive agents
- Patent Title (中): 双作用抗高血压药
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Application No.: US13755404Application Date: 2013-01-31
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Publication No.: US08735625B2Publication Date: 2014-05-27
- Inventor: Seok-ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
- Applicant: Seok-ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: C07C239/00
- IPC: C07C239/00 ; C07D257/00

Abstract:
The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
Public/Granted literature
- US20140046075A1 DUAL-ACTING ANTIHYPERTENSIVE AGENTS Public/Granted day:2014-02-13
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