Invention Grant
US08735656B2 Method of expressing galactosyltransferase and inhibiting xylosyltransferase or fucosyltransferase in a transgenic plant cell for secretory production of glycoproteins having human-type sugar chains
有权
在转基因植物细胞中表达半乳糖基转移酶和抑制木糖基转移酶或岩藻糖基转移酶以分泌具有人型糖链的糖蛋白的方法
- Patent Title: Method of expressing galactosyltransferase and inhibiting xylosyltransferase or fucosyltransferase in a transgenic plant cell for secretory production of glycoproteins having human-type sugar chains
- Patent Title (中): 在转基因植物细胞中表达半乳糖基转移酶和抑制木糖基转移酶或岩藻糖基转移酶以分泌具有人型糖链的糖蛋白的方法
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Application No.: US13616878Application Date: 2012-09-14
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Publication No.: US08735656B2Publication Date: 2014-05-27
- Inventor: Kazuhito Fujiyama , Tatsuji Seki
- Applicant: Kazuhito Fujiyama , Tatsuji Seki
- Applicant Address: US TX San Antonio
- Assignee: Phyton Holdings, LLC
- Current Assignee: Phyton Holdings, LLC
- Current Assignee Address: US TX San Antonio
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: JP2001-12519 20010119
- Main IPC: C12N15/82
- IPC: C12N15/82
Abstract:
A method for the secretory production of a glycoprotein having a human-type sugar chain, comprising a step of introducing a gene of an enzyme capable of performing a transfer reaction of a galactose residue to a non-reducing terminal acetylglucosamine residue, and a gene of heterologous glycoprotein, to obtain a transformed plant cell, a step of culturing the plant cell, and a step of recovering the culture medium of the plant cell.
Public/Granted literature
- US20130164782A1 METHOD FOR SECRETORY PRODUCTION OF GLYCOPROTEIN HAVING HUMAN-TYPE SUGAR CHAIN USING PLANT CELL Public/Granted day:2013-06-27
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