A drive mechanism of a lifting rail for a musical instrument including a lifting rail, the drive mechanism including: a connection member connected to the lifting rail; and a movement-force giving mechanism configured to move the lifting rail via the connection member, wherein the lifting rail includes: a hollow portion opening at one end; and a through-hole formed through an upright wall portion of the lifting rail, wherein the connection member includes: an insertion member having an attachment hole corresponding to the through-hole; a fixing member for connecting the lifting rail and the connection member; and a contact portion configured to come into contact with the one end of the lifting rail when the insertion member is inserted in the hollow portion by a prescribed distance so as to prevent the insertion member from being further inserted in the hollow portion, thereby positioning the attachment hole relative to the through-hole.