A drive and control circuit for motor system and the method thereof are disclosed. The motor system could be applied in a cooling device, wherein the motor system comprises a rotor, a coil and a bridge circuit. The drive and control circuit comprises a control unit, a state detecting circuit, a load determining circuit, and a startup setting circuit. The startup setting circuit makes the motor run with the maximum torque, thus to make the motor system start up easily and quickly. The load determining circuit detects the load of the motor system, thus to generate a load determining signal to determine the speed of the motor system. The control unit could be realized with few components so as to save the costs.