Methods and systems for generating high resolution composite imagery are provided. The methods and systems can create a fully-in-focus high resolution composite image by combining a number of source images in which only a part of the source image is in-focus. The composite image can be analyzed to identify portions of the composite image that satisfy an image quality metric. The capture of additional source images can be controlled based at least in part on the image analysis of the composite image. In addition, a control routine for capturing the plurality of source images can be dynamically adjusted based on the image quality of the individual source images.