A method for interference-minimizing code assignment and system parameter selection for code division multiple access (CDMA) networks is disclosed. The method is performed at a base station or mobile station configured to operate in a CDMA radio network. The method includes receiving transmissions from user devices seeking to access the CDMA radio network. A spreading code is selected for a first user device seeking to access the network, using at least one cross-correlation parameter, to reduce multiple access interference between communications involving the first user device and other devices using the CDMA network. The method does not require knowledge of the active user codes or even the codebook from which these codes are assigned. Furthermore, it does not require knowledge of bit or chip epoch or the received powers of active users. However, the method can benefit from such knowledge in several ways, examples of which are disclosed. A method for explicitly estimating the bit or chip epoch is also disclosed.