A method and system synchronizes transmission of receive data over an asynchronous digital radio frequency interface in a wireless communication device. A timing accurate strobe (TAS) re-sampler generates, using a first timing strobe synchronized to a baseband modem clock, a second timing strobe synchronized to a radio frequency integrated circuit (RFIC) clock. The TAS re-sampler forwards the second timing strobe to the RFIC to trigger a collection of data samples and initiates a count of RFIC clock cycles. The RFIC sends the data samples to a baseband First In First Out (FIFO) buffer over the asynchronous interface. In response to the count reaching a pre-determined number of RFIC clock cycles corresponding to a fixed delay, the TAS re-sampler triggers a reading of data from the FIFO buffer. The baseband modem receives data corresponding to the collection of data samples after a fixed delay from generation of the first timing strobe.