A vehicle simulation system includes a compiler module, a parser module, a wrapper module, a modeling module, and a simulation module. The compiler module generates object code that is compatible with a first type of operating system based on source code that is executable by a vehicle control module and that is compatible with a second type of operating system. The parser module generates a definitions file and an extensible markup language (XML) file based on the source code and the object code. The wrapper module generates a library file based on the object code and the definitions file. The modeling module generates model-based source code for a virtual model based on the XML file and a user configuration of the virtual model. The simulation module simulates operation of a plant of a vehicle with the virtual model.