Systems and methods for associating applications with an electronic program guide are provided. An electronic program guide that includes television schedule information organized in a grid by time and channel may be generated. The electronic program guide may be configured for presentation to a user by an electronic program guide application executed by a programming processing component associated with the user. A second application different from the electronic program guide application may be associated with an entry in the grid of the electronic program guide. The second application may be configured for execution by the programming processing component based at least in part upon the user selecting the entry. Once generated, the electronic program guide may be output for receipt by the programming processing component.