Patient simulator systems for teaching patient care are provided. In some instances, the patient simulator systems include a patient body comprising one or more simulated body portions. Generally, the patient simulator systems of the present disclosure provide physiological modeling. In one embodiment, the patient simulator includes a maternal simulator comprising a maternal circulatory model, a maternal cardiac ischemia model, and a maternal respiratory model and a fetal simulator comprising a fetal circulatory model, a fetal cardiac ischemia model, and a fetal central nervous system model. A controller in communication with the maternal and fetal simulators coordinates parameters of the maternal circulatory model, the maternal cardiac ischemia model, the maternal respiratory model, the fetal circulatory model, the fetal cardiac ischemia model, and the fetal central nervous system model to simulate physiological characteristics of a natural mother and fetus. Methods of utilizing the patient simulator systems are also provided.