Invention Grant
US08741261B2 Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via isocyanate using azides and carbon-isotope monoxide
失效
通过使用叠氮化物和碳同位素一氧化碳通过异氰酸酯过渡金属促进羰基化的碳同位素标记合成方法
- Patent Title: Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via isocyanate using azides and carbon-isotope monoxide
- Patent Title (中): 通过使用叠氮化物和碳同位素一氧化碳通过异氰酸酯过渡金属促进羰基化的碳同位素标记合成方法
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Application No.: US11086632Application Date: 2005-03-22
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Publication No.: US08741261B2Publication Date: 2014-06-03
- Inventor: Bengt Langstrom , Julien Barletta , Hisashi Doi , Masaaki Suzuki , Ryoji Noyori , Yasuyoshi Watanabe , Farhad Karimi
- Applicant: Bengt Langstrom , Julien Barletta , Hisashi Doi , Masaaki Suzuki , Ryoji Noyori , Yasuyoshi Watanabe , Farhad Karimi
- Applicant Address: GB Buckinghamshire
- Assignee: GE Healthcare Limited
- Current Assignee: GE Healthcare Limited
- Current Assignee Address: GB Buckinghamshire
- Agent Jean K. Testa
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; C07D345/00 ; C07D205/00 ; C07D213/46
Abstract:
Methods and reagents for transition metal-promoted carbonylation via isocyanate using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
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