Invention Grant
- Patent Title: APOE immunotherapy
- Patent Title (中): APOE免疫治疗
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Application No.: US13368260Application Date: 2012-02-07
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Publication No.: US08741298B2Publication Date: 2014-06-03
- Inventor: Dale B. Schenk , Tarlochan S. Nijjar , Philip W. Payne , Robin Barbour
- Applicant: Dale B. Schenk , Tarlochan S. Nijjar , Philip W. Payne , Robin Barbour
- Applicant Address: IE
- Assignee: Neotope Biosciences Limited
- Current Assignee: Neotope Biosciences Limited
- Current Assignee Address: IE
- Agency: Alston & Bird LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; C07K4/12 ; C12N5/06 ; C12N15/74 ; C12N15/81
Abstract:
The present invention provides antibodies that preferentially bind to an ApoE(1-272) fragment relative to ApoE(1-299). These antibodies serve to reduce the toxicity of this fragment and find use in treatment and prophylaxis of a variety of neurological diseases.
Public/Granted literature
- US20120204275A1 APOE IMMUNOTHERAPY Public/Granted day:2012-08-09
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