Invention Grant
- Patent Title: High yield yellow fever virus strain with increased propagation in cells
- Patent Title (中): 高产黄热病毒株在细胞中的繁殖增加
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Application No.: US13012917Application Date: 2011-01-25
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Publication No.: US08741312B2Publication Date: 2014-06-03
- Inventor: Cynthia K. Lee , Thomas P. Monath , Patrick M. Guertin , Edward G. Hayman
- Applicant: Cynthia K. Lee , Thomas P. Monath , Patrick M. Guertin , Edward G. Hayman
- Applicant Address: US NJ Piscataway
- Assignee: GE Healthcare Bio-Sciences Corp.
- Current Assignee: GE Healthcare Bio-Sciences Corp.
- Current Assignee Address: US NJ Piscataway
- Main IPC: A61K39/12
- IPC: A61K39/12 ; C12N7/00
Abstract:
The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.
Public/Granted literature
- US20110287519A1 HIGH YIELD YELLOW FEVER VIRUS STRAIN WITH INCREASED PROPAGATION IN CELLS Public/Granted day:2011-11-24
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