Invention Grant
US08741563B2 Metronidazole resistance in trichomonas vaginalis and single nucleotide polymorphisms
有权
阴道毛滴虫中的甲硝唑耐药性和单核苷酸多态性
- Patent Title: Metronidazole resistance in trichomonas vaginalis and single nucleotide polymorphisms
- Patent Title (中): 阴道毛滴虫中的甲硝唑耐药性和单核苷酸多态性
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Application No.: US13680553Application Date: 2012-11-19
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Publication No.: US08741563B2Publication Date: 2014-06-03
- Inventor: David W. Hilbert , Scott E. Gygax , Martin E. Adelson , Eli Mordechai , Jessica Schuyler , Teresa Paulish-Miller
- Applicant: Medical Diagnostic Laboratories, LLC
- Applicant Address: US NJ Hamilton
- Assignee: Medical Diagnostic Laboratories, LLC
- Current Assignee: Medical Diagnostic Laboratories, LLC
- Current Assignee Address: US NJ Hamilton
- Agent Siu K. Lo, Esq.; Christina M. Sergo, Esq.
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C12P31/00 ; C07H21/04
Abstract:
The present invention is directed to the discovery of single nucleotide polymorphisms (SNPs) in the presence of metronidazole-resistant Trichomonas vaginalis. The presence of G76C, C213G, or C318A (SNP) in tvntr 4 or the presence of A238T, G427C, or T476C (SNP) in tvntr6 provides a reliable biomarker for the presence of metronidazole-resistant Trichomonas vaginalis. The present invention further provides reagents used for detecting the SNPs to screen subjects for metronidazole resistance in Trichomonas vaginalis.
Public/Granted literature
- US20130130253A1 METRONIDAZOLE RESISTANCE IN TRICHOMONAS VAGINALIS AND SINGLE NUCLEOTIDE POLYMORPHISMS Public/Granted day:2013-05-23
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