Invention Grant
- Patent Title: Consensus coding sequences of human breast and colorectal cancers
- Patent Title (中): 人乳腺癌和结肠直肠癌的共识编码序列
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Application No.: US12377073Application Date: 2007-08-13
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Publication No.: US08741573B2Publication Date: 2014-06-03
- Inventor: Tobias Sjoblom , Sian Jones , D. Williams Parsons , Laura D. Wood , Jimmy Lin , Thomas Barber , Diana Mandelker , Bert Vogelstein , Kenneth W. Kinzler , Victor E. Velculesu
- Applicant: Tobias Sjoblom , Sian Jones , D. Williams Parsons , Laura D. Wood , Jimmy Lin , Thomas Barber , Diana Mandelker , Bert Vogelstein , Kenneth W. Kinzler , Victor E. Velculesu
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Banner & Witcoff, Ltd.
- International Application: PCT/US2007/017866 WO 20070813
- International Announcement: WO2008/021288 WO 20080221
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/53

Abstract:
Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.
Public/Granted literature
- US20100316995A1 CONSENSUS CODING SEQUENCES OF HUMAN BREAST AND COLORECTAL CANCERS Public/Granted day:2010-12-16
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