Invention Grant
US08741575B2 Methods of predicting high grade gliomas using senescence associated genes
有权
使用衰老相关基因预测高级胶质瘤的方法
- Patent Title: Methods of predicting high grade gliomas using senescence associated genes
- Patent Title (中): 使用衰老相关基因预测高级胶质瘤的方法
-
Application No.: US13597753Application Date: 2012-08-29
-
Publication No.: US08741575B2Publication Date: 2014-06-03
- Inventor: Domenico Coppola , Dung-Tsa Chen , Steven Brem
- Applicant: Domenico Coppola , Dung-Tsa Chen , Steven Brem
- Applicant Address: US FL Tampa
- Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
- Current Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
- Current Assignee Address: US FL Tampa
- Agency: Smith & Hopen, P.A.
- Agent Michele L. Lawson
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; A61K49/00
Abstract:
The present invention relates to biomarkers for neoplasias such as high grade gliomas. The inventors have discovered that the overexpression of senescence associated genes (SAG) is associated with a poor prognosis in subjects with high grade gliomas. The present invention provides SAG biomarkers for predicting response to therapy for subjects having high grade glioma based on dividing the samples into high and low risk groups; diagnosing high grade glioma; monitoring progression of high grade glioma from one biological state to another; and determining efficacy of treatment for high grade gliomas.
Public/Granted literature
- US20120322687A1 METHODS OF PREDICTING HIGH GRADE GLIOMAS USING SENESCENCE ASSOCIATED GENES Public/Granted day:2012-12-20
Information query
