Invention Grant
- Patent Title: Method for producing mast cells from pluripotent stem cells
- Patent Title (中): 从多能干细胞产生肥大细胞的方法
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Application No.: US13394666Application Date: 2010-09-08
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Publication No.: US08741644B2Publication Date: 2014-06-03
- Inventor: Tatsutoshi Nakahata , Kohichiro Tsuji , Feng Ma
- Applicant: Tatsutoshi Nakahata , Kohichiro Tsuji , Feng Ma
- Applicant Address: JP Kyoto
- Assignee: Kyoto University
- Current Assignee: Kyoto University
- Current Assignee Address: JP Kyoto
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- International Application: PCT/JP2010/065893 WO 20100908
- International Announcement: WO2011/030915 WO 20110317
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; C12N5/0787
Abstract:
The present invention relates to a method for producing human mast cells from human pluripotent stem cells. More particularly, the present invention provides a method for producing human mast cells from human pluripotent stem cells, comprising the steps of: (a) culturing human pluripotent stem cells under a condition suitable for promoting differentiation of the human pluripotent stem cells into hematopoietic progenitor cells expressing CD34; and (b) culturing the cells obtained in step (a) in the presence of hematopoietic factors comprising thrombopoietin (TPO) and Flt3 ligand.
Public/Granted literature
- US20120208206A1 METHOD FOR PRODUCING MAST CELLS FROM PLURIPOTENT STEM CELLS Public/Granted day:2012-08-16
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