Invention Grant
- Patent Title: Genetically transformed microorganisms with simultaneous enhancement of reduction potential and reductive enzyme activities for biomass fermentation
- Patent Title (中): 遗传转化的微生物同时提高还原电位和生物发酵酶还原酶活性
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Application No.: US12918534Application Date: 2009-02-16
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Publication No.: US08741652B2Publication Date: 2014-06-03
- Inventor: Siddavattam Dayananda Siddavattam , Doddala Doddala Anitha Choudary , Karthikeyan Karthikeyan Venkatanarayanan
- Applicant: Siddavattam Dayananda Siddavattam , Doddala Doddala Anitha Choudary , Karthikeyan Karthikeyan Venkatanarayanan
- Applicant Address: IN Nagarjuna Hills
- Assignee: Nagarjuna Fertilizers and Chemicals Limited
- Current Assignee: Nagarjuna Fertilizers and Chemicals Limited
- Current Assignee Address: IN Nagarjuna Hills
- Agency: DLA Piper LLP US
- Priority: IN422/CHE/2008 20080220
- International Application: PCT/IN2009/000105 WO 20090216
- International Announcement: WO2009/113101 WO 20090917
- Main IPC: C12N15/81
- IPC: C12N15/81 ; C12N1/19 ; C07H21/04
Abstract:
The present invention describes the genetic engineering of production microorganisms used in biotechnology to improve their properties so that they produce industrially useful products more efficiently from fermentable sugars derived from biomass. The engineered microorganisms endowed with functional coupling of oxidation and reduction of substrates by dehydrogenases requiring pyridine nucleotides (NAD/NADH) result in simultaneous enhancement of reduction potential enzyme activity involving the transfer of electrons. In particular, this invention relates to the construction of an excisable gene expression cassette for expression of two different dehydrogenases leading to enhanced production of ethanol.
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